Publications
2023
Matsui R, Endo K, Saiki T, Haga H, Shen W, Wang X, Yamazaki S, Katayama S, Nagata K, Kitamura H, Tanaka S. Characterization and anti-tumor activities of polysaccharide isolated from Brassica rapa L. via activation of macrophages through TLR2-and TLR4-Dependent pathways.
Arch Biochem Biophys. 752:109879, 2023.
Endo K, Sawa T, Tanaka Y, Saiki T, Haga H, Rizeq L, Aso H, Isono M, Niitsuma F, Masaki A, Makabe H, Tanaka S. Oral administration of procyanidin B2 3,3"-di-O-gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis. Eur J Pharmacol. 954:175879, 2023.
Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Tanaka S. Brassica rapa L. prevents Western diet-induced obesity in C57BL/6 mice through its binding capacity of cholesterol and fat. Biosci Biotechnol Biochem. 87(10):1205-1211, 2023.
Sawa T, Endo K, Nakashima A, Tanaka Y, Makabe H, Tanaka S. Procyanidin B2 3,3''-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells. Int Immunopharmacol. 121:110444, 2023.
Huricha, Horaguchi K, Shiiba Y, Tanaka S, Takeda K. Effects of one hour daily outdoor access on lying and sleeping postures, and immune traits of tethered cows. Anim Biosci. 36(7):1143-1149, 2023.
Tanaka S. Modulation of immune function and changes in intestinal flora by Brassica rapa L. (Nozawana). Biosci Biotechnol Biochem. 87(5):465-472, 2023.
Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S. Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2. Int Immunopharmacol. 115, 109617, 2023
2022
Asami T, Endo K, Matsui R, Sawa T, Tanaka Y, Saiki T, Tanba N, Haga H, Tanaka S. Long-term caloric restriction ameliorates T cell immunosenescence in mice. Mech Ageing Dev. 206,111710, 2022.
2021
Tanaka S, Yamamoto K, Hamajima C, Takahashi F, Endo K, Uyeno Y. Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure. Nutrients. 13(6),1847, 2021.
Takahashi F, Endo K, Matsui R, Yamamoto K, Tanaka S. Brassica rapa L. activates macrophages via Toll-like receptors. Bioscience, Biotechnology, and Biochemistry. 85, 656-665, 2021.
Endo K, Matsui R, Asami T, Sawa T, Nakashima A, Tanaka Y, Makabe H, Tanaka S. The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells. Biomedicine & Pharmacotherapy. 137, 111346, 2021.
2020
Endo K, Matsui R, Sugiyama M, Asami T, Inaba C, Kobayashi S, Makabe H, Tanaka S. Procyanidin B2 gallate regulates TNF-α production from T cells through inhibiting glycolytic activity via mTOR-HIF-1 pathway. Biochemical Pharmacology. 177,113952, 2020.
Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S. MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. Gene. 725,144191, 2020.
2019
Sandagdorj B, Hamajima C, Kawahara T, Watanabe J, Tanaka S. Characterization of Microbiota that Influence Immunomodulatory Effects of Fermented Brassica rapa L. Microbes and Environments. 34, 206-21,. 2019.
Lebetwa N, Suzuki Y, Tanaka S, Nakamura S, Katayama S. Enhanced Anti-Allergic Activity of Milk Casein Phosphopeptide by Additional Phosphorylation in Ovalbumin-Sensitized Mice. Molecules. 24(4), E738, 2019.
2018
Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S. Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain. Journal of Agricultural and Food Chemistry. 66, 7935-7941, 2018.
Yamamoto K, Furuya K, Yamada K, Takahashi F, Hamajima C, Tanaka S. Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by a Brassica rapa L. Bioscience, Biotechnology, and Biochemistry. 82, 654-668, 2018.
2017
Tanaka S, Yamamoto K, Hamajima C, Takahashi F, Yamada K, Furuya K, Uyeno Y. Changes in gut microbial ecology and immunological responses of mice fed the insoluble fraction of Brassica rapa L. that was fermented or not. Microbes and Environments. 32, 268-274, 2017.
Tanaka S, Furuya K, Yamamoto K, Yamada K, Ichikawa M, Suda M, Makabe H. Procyanidin B2 gallates inhibit IFN-γ and IL-17 production in T cells by suppressing T-bet and RORγt expression. International Immunopharmacology. 44, 87-96, 2017.
2016
Tanaka S, Yamamoto K, Yamada K, Furuya K, Uyeno Y. Relationship of enhanced butyrate production by colonic butyrate-producing bacteria and immunomodulatory effects in normal mice fed insoluble fraction of Brassica rapa L. Applied and Environmental Microbiology. 82, 2693-2699, 2016.
2015
Kabir F, Tow WW, Hamauzu Y, Katayama S, Tanaka S, Nakamura S. Antioxidant and cytoprotective activities of extracts prepared from fruit and vegetable wastes and by-products. Food Chemistry. 15, 358-362. 2015.
Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T. Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice. Molecular Therapy. 23, 297-309, 2015.